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BIOPROCESS DIGITAL PROFESSIONAL COURSES
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Simulation, scale-up, optimal operation of suspended and adherent animal cell bioreactors

Animal cells culture processes

ONLINE COURSE: On-demand

COURSE FEE: 300 € per session 

COURSE ORGANIZATION

Course organized in 6 sessions

Sessions scheduling: at your pace

Effort: 4 - 8 hours per session

COURSE DESCRIPTION

The course teaches the methodology of the kinetic analysis, the knowledge-type modeling-simulation, the scale-up, and the optimal operation of animal cell bioreactors. The guiding thread of the course is a R&D project on CHO or Vero cells cultures.The industrial bioreactor operation is digitally optimized in batch, fed-batch and perfusion modes, for the production of cells, proteins or viruses.

INSTRUCTOR​

  • Jean-Marc ENGASSER, BioProcess Digital

DIGITAL LEARNING​

  • Learning platform with course resources

  • Live or recorded slideshow videos

  • Spreadsheet simulators with guides for bioreactors optimization

  • Online collective or one-to-one tutoring

COURSE PROGRAM

SESSION 1: ​KINETIC ANALYSIS OF CELL CULTURES

At the laboratory, evaluation of the rates of cells growth and death, substrates consumption, and metabolites production

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SESSION 2: ​KINETIC ANALYSIS OF OXUGEN CONSUMPTION AND TRANSFER

Determination, during the culture, of the oxygen consumption rate, solubility, and air to medium transfer rate

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SESSION 3: ​BIOREACTOR KNOWLEDGE-MODEL FOR CULTURES SIMULATION

Based on the influencing b biochemical and physical phenomena, construction of the bioreactor simulation model for cells growth and death, glucose, glutamine and oxygen consumptions, and lactate, ammonia, and CO2 productions

 

SESSION 4: ​BIOREACTOR  SCALE-UP AND OPTIMAL OPERATIONS FOR CELLS PRODUCTION

Scale-up of the bioreactor simulation model. Digital optimization of the bioreactor batch, fed-batch and perfusion operations for the highest cells production

 

SESSION 5: ​BIOREACTOR OPTIMAL OPERATIONS FOR RECOMBINANT PROTEINS PRODUCTION

Digital optimization of the bioreactor batch, fed-batch and perfusion operations for the highest proteins production

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SESSION 6: ​BIOREACTOR OPTIMAL OPERATIONS FOR VIRUS PRODUCTION

Simulation model of the adherent cell bioreactor. Digital optimization of the bioreactor batch, fed-batch and perfusion operations for the highest virus production

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