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BIOPROCESS DIGITAL PROFESSIONAL COURSES
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Simulation, scale-up, and optimization of soluble and immobilized enzymes bioreactors

Enzymatic bioconversion processes

ONLINE COURSE: On-demand

COURSE FEE: 300 € per session  

COURSE ORGANIZATION

Course organized in 8 sessions

Sessions scheduling: suggested one seesion per week

Effort: 4 - 8 hours per session

COURSE DESCRIPTION

The course teaches the methodology of the kinetic analysis, the modeling-simulation, the scale-up, and the optimization of soluble and immobilized enzymes bioreactors.

The guiding thread of the course is a virtual R&D project on starch bioconversion by a glucoamylase enzyme. The objective is to design the most cost-efficient industrial bioreactor to hydrolyze maltodexrins into glucose. 

INSTRUCTOR​S

  • Isabelle CHEVALOT, Professor ENSAIA, Nancy

  • Jean-Marc ENGASSER, BioProcess Digital

WHAT YOU'LL LEARN ​

  • Design and analyze experiments to determine the kinetics of enzymatic reactions

  • Construct simulation models of soluble and immobilized enzymes reactors

  • Use simulators to scale up and optimize batch and continuous enzyme bioreactors

  • Evaluate the cost of enzymatic bioconversions

  • Determine the bioreactors operational variables (temperature, enzyme concentration) to reach the lowest bioconversion cost

DIGITAL LEARNING​

  • Learning platform with course resources

  • Live or recorded slideshow videos

  • Bioconversion project on spreadsheets templates with self-corrections and guides

  • Online collective or one-to-one tutoring

COURSE PROGRAM

SESSION 1: KINETIC ANALYSIS OF THE ENZYMATIC BIOCONVERSION

At the laboratory, kinetic analysis of the enzymatic reaction and denaturation. Influence of temperature

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SESSION 2: MODELING-SIMULATION OF THE ENZYMATIC BIOCONVERSION

Modeling-simulation of the bioconversion in the batch reactor. Influence of temperature and enzyme concentration

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SESSION 3: SCALE-UP AND OPTIMIZATION OF THE BIOCONVERSION IN A BATCH REACTOR

Scale-up of the simulation model. Cost evaluation of the bioconversion. Optimal operation of the batch reactor

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SESSION 4: OPTIMIZATION OF THE BIOCONVERSION IN A CONTINUOUS STIRRED REACTOR

Simulation and optimal operation of the bioconversion in the continuous stirred reactor

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SESSION 5: OPTIMIZATION OF THE BIOCONVERSION IN A CONTINUOUS TUBULAR REACTOR

Simulation and optimal operation of the bioconversion in the continuous tubular reactor

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SESSION 6: OPTIMIZATION OF THE BIOCONVERSION IN A MEMBRANE BIOREACTOR

Simulation and optimal operation of the bioconversion in the continuous membrane reactor

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SESSION 7: MODELING-SIMULATION OF THE IMMOBILIZED ENZYME KINETICS

Modeling-simulation of the bioconversion by immobilized enzymes. Influence of diffusional limitations

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SESSION 8: SCALE-UP AND OPTIMIZATION OF THE BIOCONVERSION IN A FIXED-BED REACTOR

Simulation and optimal operation of the bioconversion in the immobilized enzymes fixed-bed reactor

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